Levofloxacin enantioselective voltammetric sensing based on functionalized fullerene

---

Authors

Liana Zagitova¹ , Ilya Abramov¹ , Svetlana Gainanova¹

1. Ufa University of Science and Technology

Conference / event

Asian Symposium on Advanced Materials (ASAM-8), July 2023 (Novosibirsk, Russian Federation)

Poster summary

In this work, a number of selectors containing a chiral blocks from a simple, accessible enantiopure compound of R- and S-alphamethylbenzylamine was synthesized. The chiral blocks were attached to fullerene (C60) through an intermediate adduct with dichloroacetic and malonic acids using the Bingel-Hirsch reaction, the structure of which was confirmed by NMR and IR spectroscopy. The sensitive layer of studied sensors consisted of layer-by-layer deposited graphene oxide and functionalized C60. The proposed sensors were characterized by cyclic voltammetry and electrochemical impedance spectroscopy. Morphological studies of sensors were carried out using scanning electron microscopy. Some patterns of changes in the electrochemical behavior of Lev depending on the composition of the sensitive layer of the sensor were obtained. Quantitative determination of Lev was carried out by differential pulse voltammetry. Moreover, the developed sensor can be used to detect Lev in real samples (biological fluids and tablet) with a good recovery percentage.

Keywords

Enantioselective voltammetric sensor, Functionalized fullerene, Reduced graphene oxide, Fluoroquinolone antibiotics, Levofloxacin, Chiral blocks

Research areas

Chemistry, Material Sciences

References

1. Zagitova Liana, Abramov Ilya, Zagitov Vadim, Gainanova Svetlana, Maistrenko Valery. Effect of the chiral blocks of functionalized fullerene on levofloxacin enantioselective voltammetric sensing// J. Electroanal. Chem. 2023. V. 940. N 117508.
2. V.N. Maistrenko, G.A. Evtugyn, Enantioselective Sensors, Laboratory of Knowledge, Moscow (2023) ISBN 978–5–93208-524-6.

Funding

1. Russian Science Foundation (No. 22- 73-00073)

Supplemental files

No data provided

Additional information

Competing interests

No competing interests were disclosed.

Data availability statement

The datasets generated during and / or analyzed during the current study are available from the corresponding author on reasonable request.

Creative Commons license

Copyright © 2023 Zagitova et al. This is an open access work distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.