Association of gut microbiota with inflammatory bowel disease and COVID-19 severity: A possible outcome of the altered immune response

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Authors

Anju Kaushal¹

1. New Zealand Organization for Quality ( NZOQ), New Zealand

Conference / event

"2nd Edition of World Congress on Infectious Diseases" online Conference by Magnus Group Conferences, June 2022 (Virtual)

Poster summary

Microbiome structure influences the innate and adaptive immune response that could cause dysbiosis often linked to infectious diseases, rheumatoid arthritis, cancer, obesity, and cardiovascular diseases. Gut and lung microflora delivers immunomodulatory functions, but it’ll undertake the path to get substituted by pathogens leading to a poor prognosis of COVID-19. Mucosal cell lining enhances the relocation of SARSCoV-2 due to increased ACE-2 receptors, resulting in excessive transcription of proinflammatory cytokines via P38 MAPK and AP-1 pathway mainly through exhaustive macrophages and monocytes. Which eventually reduces the production of TLRs, NODs-NLRs, and SCFAs depleting the resident microflora to affect overall homeostasis. Injured mucosal lining enhances the systemic translocation of bacteria (pathogens and commensals), cell metabolites, cytokines, chemokines, and other toxins to other organs causing multiorgan injuries.

Keywords

COVID-19, Pathogens, Microbiome, Immune response, Gut and lung microflora

Research areas

Biological Sciences, Immunology, Microbiology, Medicine

References

1. Kaushal Anju, Noor Rashed ( 2022) Association of Gut Microbiota with Inflammatory Bowel Disease and COVID-19 severity: A possible outcome of the altered immune response. Current Microbiology 79:184.https://link.springer.com/article/10.1007/s00284-022-02877-7

Funding

1. N/A

Supplemental files

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Additional information

Competing interests

No competing interests were disclosed.

Data availability statement

Data sharing not applicable to this poster as no datasets were generated or analyzed during the current study.

Creative Commons license

Copyright © 2023 Kaushal. This is an open access work distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.