Sympathetic Neural Contributions to Vascular Control: Role of KATP Channels

Authors

Clark Holdsworth¹ , Scott Ferguson¹ , Richard Fels¹ , Shawnee Montgomery¹ , Michael Kenney¹ , David Poole¹ , Timothy Musch¹

1. Kansas State University

Conference / event

Experimental Biology, March 2015 (Boston, MA, United States)

Poster summary

The ATP-sensitive K+ (KATP) channel is a class of inward rectifier K+ channels that contributes to systemic basal vasomotor tone. In rats blockade of KATP channels via glibenclamide (GLI) promotes vasoconstriction thereby increasing mean arterial pressure (MAP) and decreasing renal and hindlimb skeletal muscle blood flow. We tested the hypothesis that the GLI-induced increase in vascular tone resulted, in part, from increased renal or lumbar sympathetic nerve discharge (SND). Heart rate (HR), MAP and lumbar and renal SND (direct nerve recordings) were measured in 8 male Sprague Dawley rats for 10 min following vehicle (VEH) and GLI (2.5 mg/kg i.v.). GLI-induced reductions in skeletal muscle and renal blood flow reflect peripheral KATP channel vascular control and decreased SND actually acts to constrain the full magnitude of the hyperemic response. Consequently, the hindlimb skeletal muscle blood flow reductions with KATP channel blockade may be underestimated in baroreflex-intact animals.

Keywords

autonomic control, microvascular, microcirculation

Research areas

Anatomy and Physiology

References

No data provided

Funding

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Supplemental files

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Additional information

Competing interests

No competing interests were disclosed.

Data availability statement

The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.

Creative Commons license

Copyright © 2022 Holdsworth et al. This is an open access work distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.