DoD Bone Marrow Failure, Investigator-Initiated Research Award

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Grant Name

Funder

Army Medical Research Acquisition Activity (AMRAA)

Department of Defense (DOD)

Country or Region

United States

Research Field

Science and Technology and other Research and Development

Deadline

Oct 09, 2024 12:00:00 AM EDT

Grant Size

2440000

Contact Info

Christopher L Baker Grants Officer Help@eBRAP.org

Eligibility

Eligible Applicants:

Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled "Additional Information on Eligibility"

Grant Number

HT942524BMFRPIIRA

Description

The FY24 BMFRP Investigator-Initiated Research Award (IIRA) will offer two funding levels with different intent:

Funding Level 1 (FL1): To support studies that further develop mature ideas, expand upon key discoveries, and have the potential to make significant advances in research and/or patient care in the FY24 BMFRP Focus Areas. IIRA applications may involve translational and clinical research including studies in animal models, research with human data and/or anatomical substances, and research with human subjects, as well as correlative studies associated with a clinical trial(s); however, FL1 awards may not be used to support a clinical trial. An application that proposes a correlative study should be associated with a clinical trial(s), and the proposed study should address critical knowledge gaps in clinical outcomes, validate key research results, expand upon potentially game-changing results, or other impactful outcomes. Multidisciplinary collaborations are encouraged.

Funding Level 2 (FL2): To support Investigational New Drug (IND) application-enabling efforts. The BMFRP recognizes the scientific and financial challenges associated with advancing promising, potentially life-changing, therapeutic agents from the laboratory to clinical evaluation. Data related to lead compound characterization; formulation and stability; absorption, distribution, metabolism and excretion; dose/response; and toxicology are required before clinical trials can commence. The proposed studies under the FL2 IND-enabling efforts are expected to be empirical in nature, product-driven, and focused on the accumulation of data for a lead therapeutic candidate that will be included in an IND application submission to the U.S. Food and Drug Administration (FDA). At least one and no more than three lead therapeutic candidates must be named at the time of application submission to meet the intent of the FL2 mechanism. Library screening or drug optimization studies do not meet the intent of FL2. The intent of FL2 awards is to perform the necessary evaluation of promising therapies that will lead to clinical trials; however, clinical trials themselves are not supported by this mechanism. FL2 applications must address the FY24 BMFRP Focus Area, “Find effective BMF treatments and cures.”

Funding resources
Purdue Grant Writing Lab: Introduction to Grant Writing	Open Link
University of Wisconsin Writing Center: Planning and Writing a Grant Proposal	Open Link

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Oct 09, 2024 12:00:00 AM EDT

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