Loutfy H. Madkour
Egypt Tanta University
Published in 2023
- Effetti tossici dei metalli pesanti ambientali sulla fisiopatologia cardiovascolare ((Italian edition))
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Effetti tossicimetalli pesantifisiopatologiacardiovascolare - Authors: Loutfy H. Madkour
- Journal: Journal LAMBART Academic Publishing
- Description:
- Trentacinque metalli rappresentano una minaccia per la salute umana, 23 dei quali sono metalli pesanti [1]. Gli studi riportano diversi effetti dei metalli pesanti nell'acqua potabile [2,3]. Secondo l'Agenzia Internazionale per la Ricerca sul Cancro (IARC), l'As e il Cd inorganici sono classificati come cancerogeni per l'uomo [4]. La tossicità dei metalli pesanti è una considerazione importante negli studi medici; a livelli molto elevati, la maggior parte dei metalli pesanti può causare problemi di salute per i quali non sono state trovate cause o soluzioni. I metalli pesanti vengono continuamente rilasciati nell'ambiente terrestre da fonti naturali e da attività umane, si accumulano nell'ambiente e successivamente contaminano la catena alimentare. https://www.amazon.co.uk/Effetti-tossici-ambientali-fisiopatologia-cardiovascolare/dp/6205711184/ref=sr_1_1?fbclid=IwAR09nOFpxLtYO4aedRJy2Ybga7uNFtu3gcK_XZ8cSTLUlN4jpYDwivUEjyU&qid=1694810207&refinements=p_27%3ALoutfy+H.+Madkour&s=books&sr=1-1
Published in 2023
- Eco-friendly Green Biosynthesized Metallic Nanoparticles and Biotechnological Applications in Pharmaceuticals Sciences
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Green BiosynthesizedMetallic NanoparticlesBiotechnological ApplicationsPharmaceuticals Sciences - Authors: Loutfy H. Madkour
- Journal: Journal of Materials Science and Engineering B 13 (1-3) (2023) 1-69
- Description:
- The next years will prove the importance of greensynthesis methods for MNPs and MONPs production because they are not only easy to execute, fast, and cheap but also less toxic and environmentally ecofriendly. Nanoparticle synthesis using microorganisms and plants by green synthesis technology is biologically safe, cost-effective, and environment-friendly. Plants and microorganisms have established the power to devour and accumulate inorganic metal ions from their neighboring niche. The biological entities are known to synthesize nanoparticles bothextra and intracellularly. The capability of a living system to utilize its intrinsic organic chemistry processes in remodeling inorganic metal ions into nanoparticles has opened up an undiscovered area of biochemical analysis. Metal nanoparticles (MNPs) and metal oxide nanoparticles (MONPs) are used in numerous fields. The new nano-based entities are being strongly generated and incorporated into everyday personal care products, cosmetics, medicines, drug delivery, and clothing toimpact industrial and manufacturing sectors, which means that nanomaterials commercialization and nanoassisted device will continuously grow. They can be prepared by many methods such as green synthesis and the conventional chemical synthesis methods. The green synthesis of nanoparticles (NPs) using living cells is a promising and novelty tool in bionanotechnology. Chemical and physical methods are used to synthesize NPs; however, biological methods are preferred due to its eco-friendly, clean, safe, cost effective, easy, and effective sources for high productivity and purity. Greensynthesis includes infinite accession to produce MNPs and MONPs with demanding properties. The structure–function relationships between nanomaterials and key information for life cycle evaluation lead to the production of high execution nanoscale materials that are gentle and environmentally friendly. Majority of plants have features as sustainable and renewable suppliers compared with microbes and enzymes, as they have the ability to pick up almost 75% of the light energy and transform it into chemical energy, contain chemicals like antioxidants and sugars, and play fundamental roles in the manufacture of nanoparticles. Plants considered the main factory for the green synthesis of MNPs and MONPs, and until now, different plant species have been used to study this, but the determined conditions should be taken into consideration to execute this preparation.
Published in 2023
- Corrosion Resistance Potential of Metal-Matrix Composites Reinforced With Carbon Nanofibers and Carbon Nanotubes
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Corrosion ResistanceMetal-MatrixCompositesCarbon Nanotubes - Authors: Loutfy Madkour
- Journal: Handbook of Research on Corrosion Sciences and Engineering
- Description:
- Carbon nanotubes are attractive and promising fillers due to their chemical inertness and high mechanical, electrical, and thermal properties. From the conjugation of carbon nanotubes with inorganic hybrid, it is expected to obtain nanocomposite coatings that combine high anti-corrosion efficiency with improved mechanical stability. This book chapter presents a concise review of microstructure and corrosion behaviour of different nanotube composite coatings. In the first section, the authors briefly explain the science behind the corrosion and corrosion resistance of nanotube composite coatings, followed by a selection of current state and recent advances on promoted nanotube composite coating: Al, Cu, Mg, Fe, Ni, Mg–Zn, Mg–Al, NiCo, and ZnCo-carbon nanotube composite and based matrix composites coatings. Recent development of graphene reinforced metal matrix nanocomposites has been studied. Challenges needed to be rectified before the synthesis of metal-matrix nanocomposites. Finally, the authors discuss the relevant topics, highlighting recent progress and unresolved questions.
Published in 2023
- Anticorrosive Carbon-Based Polymer and Epoxy Nanocomposite Coatings
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AnticorrosiveCarbon-BasedPolymer and EpoxyNanocomposite Coatings - Authors: Loutfy Madkour
- Journal: Handbook of Research on Corrosion Sciences and Engineering
- Description:
- Carbon is used as a reinforcing phase in carbon-fiber reinforced polymer composites employed in aeronautical and other technological applications. Degradation of composite occurs under polarization in aqueous media. Epoxy-based coatings have gained significant research interest owing to sufficient hydrophobicity, conductivity, water transport behaviour, and corrosion resistance. Furthermore, the anti-corrosive polymer coatings with low nanotube content have shown enhanced surface hydrophobicity and anti-rusting properties in addition to strength, conductivity, and thermal resistance. Also, polymer base coatings assessing the strength of bonding of the coating to the substrate, and salt spray test are common. This book chapter highlights the potential corrosion challenges in multi-material combinations containing carbon-fiber reinforced polymers, the surface chemistry of carbon, its plausible effects on the electrochemical activity of carbon, and consequently the degradation processes on carbon-fiber reinforced polymers.
Published in 2023
- Graphitic Carbon Nitride Quantum Dots (g-C3N4): Fundamentals and Applications
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g-C3N4)Graphitic Carbon NitrideQuantum DotsFundamentals and Applications - Authors: Loutfy H. Madkour
- Journal: International Research Journal of Basic and Clinical Studies Vol. 8(4) pp. 1-14, August, 2023
- Description:
- As a novel C and N based two-dimensional material, graphitic carbon nitride quantum dots (g-C3N4) QDsis regarded as a new generation of photocatalyst and has been widely used in the field of environmentalphotocatalysis. In recent years, graphitic carbon nitride has become one of the very exciting sustainablematerials, due to its unusual properties and promising applications as a heterogeneous catalyst in water splittingand organic contaminant degradation. A variety of modifications have been reported for this nanostructuredmaterial with the use of carbonaceous materials to enhance its potential applications. Carbon nitrides (C3N4)are renowned organic semiconductors with a band gap of 2.7 eV, which are connected via tri-s-triazine-basedforms. Graphitic carbon nitride (g-C3N4) is considered as an attractive, efficient and newly generated promisingvisible light–driven photocatalyst ascribable material owing to its distinct properties such as metal free, suitableband gap, chemical inertness and high physicochemical stability. Nevertheless, the photocatalytic activity ofpure g-C3N4 was limited by the fast recombination rate of photoinduced electron–hole pairs, poor photoexcitedcharge separation, limited range of visible light absorption and relatively low specific surface area. Enhancedphotocatalytic activity is achievable by the construction of homojunction nanocomposites to reduce the undesiredrecombination of photogenerated charge carriers. The formed g-C3N4 isotype heterojunction photocatalystmanifested significant improvement photocatalytic hydrogen production than the single and pure g-C3N4 sample.This significant enhanced photocatalytic performance is mainly ascribed to inhibited recombination, enrichedactive site and enlarged specific surface area. Hence, current chapter on g-C3N4 mainly focuses on basics,properties, and fundamentals of its synthesis and its applications with an aim to improving its photocatalyticperformance. In this chapter, the background of photocatalysis, mechanism of photocatalysis, and the severalresearches on the heterostructure graphitic carbon nitride (g-C3N4) semiconductor are discussed. This researchgives a useful knowledge on the heterostructure g-C3N4 and their photocatalytic mechanisms and applications.Finally, the challenges and future research directions of g-C3N4 photocatalysts are summarized to promotetheir environmental applications. The advantages of the heterostructure g-C3N4 over their precursors are alsodiscussed. The conclusion and future perspectives on this emerging research direction are given (12) (PDF) Graphitic Carbon Nitride Quantum Dots (g-C3N4): Fundamentals and Applications. Available from: https://www.researchgate.net/publication/373598474_Graphitic_Carbon_Nitride_Quantum_Dots_g-C3N4_Fundamentals_and_Applications?fbclid=IwAR2viFWw99PN-mzYhtx6GWDWFk4klA5nBKs5WhkCQgX9G98kwomA-iCn_6c [accessed Sep 14 2023].
Published in 2022
- Nanoparticle-Based Drug Delivery in Cancer Treatment
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NanoparticlesDrug DeliveryCancer Treatment - Authors: Loutfy H. Madkour
- Journal: Journal Taylor & Francis eBooks
- Description:
- The careful choice of nanoparticles as targets and in drug delivery routes enhances therapeutic efficacy in cancer. Nanoparticle-Based Drug Delivery in Cancer Treatment discusses nanotechnological developments of interfering RNA-based nanoparticles, delivery vehicles, and validated therapeutic RNAi–molecular target interactions and explains the results of clinical and preclinical trials. The book also gives strategies for universal methods of constructing hybrid organic–inorganic nanomaterials that can be widely applied in the biomedical field. Key Features: Reviews recent advances of nanoparticle-mediated siRNA delivery systems and their application in clinical trials for cancer therapy Focuses on material platforms that establish NPs and both localized and controlled gene silencing Emphasizes the most promising systems for clinical application Surveys progress in nanoparticle-based nanomedicine in cancer treatment Describes the most advanced of the nonviral nanocarriers for delivery of oligonucleotides to malignant blood cancer cells This book is a valuable resource for researchers, professors, and students researching drug delivery, gene carriers, cancer therapy, nanotechnology, and nanomaterials.
Published in 2022
- RNA Delivery Function for Anticancer Therapeutics
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RNA DeliveryFunctionAnticancer Therapeutics - Authors: Loutfy H. Madkour
- Journal: Journal Taylor & Francis eBooks
- Description:
- This book presents an overview of the current status of translating the RNAi cancer therapeutics in the clinic, a brief description of the biological barriers in drug delivery, and the roles of imaging in aspects of administration route, systemic circulation, and cellular barriers for the clinical translation of RNAi cancer therapeutics, and with partial content for discussing the safety concerns. It then focuses on imaging-guided delivery of RNAi therapeutics in preclinical development, including the basic principles of different imaging modalities, and their advantages and limitations for biological imaging. With growing number of RNAi therapeutics entering the clinic, various imaging methods will play an important role in facilitating the translation of RNAi cancer therapeutics from bench to bedside. RNAi technique has become a powerful tool for basic research to selectively knock down gene expression in vitro and in vivo. Our scientific and industrial communities have started to develop RNAi therapeutics as the next class of drugs for treating a variety of genetic disorders, such as cancer and other diseases that are particularly hard to address with current treatment strategies. Key Features Provides insight into the current advances and hurdles of RNAi therapeutics. Accelerates RNAi, miRNAs, and siRNA drug development for cancer therapy from bench to bedside. Addresses various modifications and novel delivery strategies for miRNAs, piRNAs and siRNA delivery in anticancer therapeutics. Explores the need for the interaction of hematologists, cell biologists, immunologists, and material scientists in the development of novel cancer therapies. Describes the …
Published in 2022
- RNA Delivery Function for Anticancer Therapeutics (Nanotechnology for Drugs, Vaccines and Smart Delivery Systems)
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RNA Delivery FunctionAnticancer TherapeuticsNanotechnology for DrugsVaccines and Smart - Authors: Loutfy H. Madkour
- Journal: Publisher : CRC Press; 1st edition (25 Jan. 2022)
- Description:
- This book presents an overview of the current status of translating the RNAi cancer therapeutics in the clinic, a brief description of the biological barriers in drug delivery, and the roles of imaging in aspects of administration route, systemic circulation, and cellular barriers for the clinical translation of RNAi cancer therapeutics, and with partial content for discussing the safety concerns. It then focuses on imaging-guided delivery of RNAi therapeutics in preclinical development, including the basic principles of different imaging modalities, and their advantages and limitations for biological imaging. With growing number of RNAi therapeutics entering the clinic, various imaging methods will play an important role in facilitating the translation of RNAi cancer therapeutics from bench to bedside. RNAi technique has become a powerful tool for basic research to selectively knock down gene expression in vitro and in vivo. Our scientific and industrial communities have started to develop RNAi therapeutics as the next class of drugs for treating a variety of genetic disorders, such as cancer and other diseases that are particularly hard to address with current treatment strategies. Key Features Provides insight into the current advances and hurdles of RNAi therapeutics. Accelerates RNAi, miRNAs, and siRNA drug development for cancer therapy from bench to bedside. Addresses various modifications and novel delivery strategies for miRNAs, piRNAs and siRNA delivery in anticancer therapeutics. Explores the need for the interaction of hematologists,cell biologists, immunologists, and material scientists in the development of novel cancer therapies. Describes the current status of clinical trials related to miRNA and siRNA-based cancer therapy Presents remaining issues that need to be overcome to establish successful therapies.
Published in 2022
- Nanoparticle-Based Drug Delivery in Cancer Treatment (Nanotechnology for Drugs, Vaccines and Smart Delivery Systems)
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NanoparticlesDrug DeliveryCancer TreatmentNanotechnology - Authors: Loutfy H. Madkour
- Journal: Publisher CRC Press
- Description:
- The careful choice of nanoparticles as targets and in drug delivery routes enhances therapeutic efficacy in cancer. Nanoparticle-Based Drug Delivery in Cancer Treatment discusses nanotechnological developments of interfering RNA-based nanoparticles, delivery vehicles, and validated therapeutic RNAi–molecular target interactions and explains the results of clinical and preclinical trials. The book also gives strategies for universal methods of constructing hybrid organic–inorganic nanomaterials that can be widely applied in the biomedical field. Key Features: Reviews recent advances of nanoparticle-mediated siRNA delivery systems and their application in clinical trials for cancer therapy Focuses on material platforms that establish NPs and both localized and controlled gene silencing Emphasizes the most promising systems for clinical application Surveys progress in nanoparticle-based nanomedicine in cancer treatment Describes the most advanced of the nonviral nanocarriers for delivery of oligonucleotides to malignant blood cancer cells This book is a valuable resource for researchers, professors, and students researching drug delivery, gene carriers, cancer therapy, nanotechnology, and nanomaterials.
Published in 2022
- Pharmacogenomics-Synergistic Strategies Using a Chimerical Peptide for Enhanced Chemotherapy Based on ROS and DNA Nanosystem
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positive feedback strategyROS-responsivedrug deliverymesoporous silica nanoparticle - Authors: Loutfy H. Madkour
- Journal: Biotechnology and Bioprocessing. 3(2): DOI: 10.31579/2766-2314/071
- Description:
- Co-delivery of gene and drug for synergistic therapy has provided a promising strategy to cure devastating diseases. The use of genomic predictors of response to cisplatin and pemetrexed can be incorporated into strategies to optimize therapy for advanced solid tumors. Here, a positive feedback strategy was utilized to amplify the concentration of intracellular reactive oxygen species (ROS) and a ROS-triggered self-accelerating drug release nanosystem (defined as T/D@RSMSNs) was demonstrated for enhanced tumor chemotherapy. It was found that in human breast cancer (MCF-7) cells, T/D@RSMSNs could not only release DOX and a-TOS initiatively, but also lead to increased concentration of intracellular ROS, which could be used as new trigger to cut away TK linkage and then in turn facilitate the further release of DOX for enhanced chemotherapy. Standard treatment for advanced non–small-cell lung cancer (NSCLC) includes the use of a platinum-based chemotherapy regimen. This novel ROS triggered self-accelerating drug release nanosystem with remarkably improved therapeutic effects could provide a general strategy to branch out the applications of existing ROS-responsive drug delivery systems (DDSs).