This study explores how different T cell subpopulations, including naive and effector T cells, migrate through human brain choroid plexus cells (HIBCPP) during Echovirus 30 (E-30) infection. It finds that Th1 effector cells and enterovirus-specific effector T cells are more efficient at migrating through these cells compared to naive T cells, with significant changes in the HIBCPP barrier function and T cell phenotypes during migration.
This study reveals that citrullination, a biochemical modification of myelin, induces a unique microglial response and inhibits spontaneous remyelination in a mouse model of demyelination. Neutralizing tumor necrosis factor α (TNFα), which is increased by citrullinated myelin, restores normal remyelination, suggesting potential therapeutic strategies for inflammatory demyelinating disorders.
This study investigates the role of the dopamine receptor D3 (DRD3) in B cells in mouse models of multiple sclerosis (MS). It finds that DRD3 in B cells plays a dual role in central nervous system (CNS) autoimmunity: promoting CNS-tropism of pro-inflammatory B cells with antigen-presenting functions, and enhancing CNS-homing of anti-inflammatory B cells, thereby acting as a critical regulator in CNS-autoimmunity.
This study improved the solubility and oral bioavailability of α-mangostin, a pharmacologically potent but poorly soluble compound, by forming solid dispersions with polyvinylpyrrolidone. The resulting nanomicelles showed increased solubility, efficient cellular uptake via endocytosis, and enhanced antitumor efficacy.
This study evaluates the effectiveness of different forecasting models in the FMCG sector by comparing statistical methods and machine learning techniques, particularly Artificial Neural Networks (ANN), using sales data from 2014-2019, and finds that ANN provides more accurate demand predictions, especially in the supplements category, with a growing trend in baby products, suggesting the potential use of the ARIMAX model for future multivariate data analysis.
Interesting talk-"Endocrinology and Environment - The Exposome of Endocrine Disease" highlights the intricate interaction between environmental factors and hormonal systems, exploring how external exposures throughout a person's life, or their 'exposome', can significantly influence the development and progression of endocrine diseases.
Precision Genome Surgery for Imprecision Medicine represents a cutting-edge approach in medical treatment, where highly targeted and specific genetic modifications are employed to address the unique and variable aspects of individual patient's conditions, thereby moving away from the one-size-fits-all approach of traditional medicine. This method signifies a significant advancement in personalized medicine, focusing on tailoring treatments to each patient's genetic makeup for more effective and precise outcomes.
This review suggests that a vegan diet, with its low levels of saturated fats, high phytonutrients, and quercetin, may benefit Alzheimer's disease prevention, but it lacks conclusive evidence compared to other diets and risks deficiencies in essential nutrients like vitamin B12 and DHA, which are crucial for cognitive health.
The "Risks and Benefits of a Vegan Diet" study, comparing 36 vegans and 36 omnivores, found no significant differences in various inflammatory biomarkers. However, a longer duration on a vegan diet positively correlated with certain biomarkers like resistin and interleukins. The study also highlighted the role of BMI and waist circumference in influencing inflammation, suggesting further research is needed to understand how a vegan diet impacts chronic disease risk through inflammation.
This review analyzes the impact of vegan diets on metabolic syndrome, noting that while veganism, driven by ethical, health, and environmental reasons, can promote health and reduce chronic disease risks if well-balanced, it may lead to nutrient deficiencies like vitamin B12 if not properly managed, necessitating supplements or fortified foods.
This review challenges misconceptions about vegan diets causing skin disorders due to nutritional deficiencies, showing that while there are individual cases of skin disease linked to vitamin B2 and A deficiencies in vegans, a well-planned vegan diet can sufficiently provide essential nutrients for skin health and may even benefit inflammatory skin conditions like acne and psoriasis.
The unchecked release of organic and inorganic waste from industrial and domestic sources poses a significant environmental threat, necessitating global action to develop and use complex resins, such as Metal-Organic Frameworks with their high surface area and functional groups, for effective pollutant removal.
I found this: https://research.com/scientists-rankings/best-scientists#google_vignette
The 2nd edition of Research.com ranking of leading scientists in the world is based on information acquired from Microsoft Academic Graph on 21-12-2022. Position in the ranking is based on a researcher’s general H-index.
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