The study investigates the role of Lis1, a key regulator of the motor protein dynein, in mitotic cell division, particularly how it aids in the removal of the fibrous corona from kinetochores, a critical process for proper chromosome segregation. HeLa cells lacking Lis1 exhibit an inability to disassemble the corona, leading to delays in metaphase due to ongoing spindle assembly checkpoint activation. The research demonstrates that while kinetochore-bound Lis1-dynein is crucial for accurate microtubule attachment, Lis1's role in corona disassembly can also be performed by Lis1 located in the cytoplasm. These findings highlight Lis1's essential contribution to dynein's function in ensuring the proper progression of mitosis and preventing chromosome mis-segregation, which is vital for understanding diseases like lissencephaly that are linked to Lis1 mutations.
Interesting article! This research explores the creation of novel biomolecular motors by combining protein modules from different cytoskeletal systems, resulting in hybrid motors that merge a dynein motor core with actin-binding proteins (ABPs). These hybrids demonstrate the capability to drive actin filament movement in a nucleotide-dependent manner, with the unique ability to reverse the direction of movement by altering the arrangement of the motor core and ABP.
The findings highlight the RH1 domains of JIP3 as critical sites for motor protein interaction, underscoring the complex interplay between JIP3-bound dynein and kinesin-1 in the bidirectional transport of organelles. This study sheds light on the molecular mechanisms by which JIP3 coordinates motor proteins to prevent lysosome accumulation in neurons, offering insights into the broader understanding of axonal transport and its implications for neurobiology.
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The conference Robotics: Science and Systems was held at the University of Washington in Seattle, from June 28 to July 1, 2009. More than 300 international researchers attended this single-track conference to learn about the most exciting robotics research and most advanced robotic systems. The program committee selected 39 papers out of 154 submissions. The program also included invited talks. The plenary presentations were complemented by workshops.
AI / machine learning related journal published by Nature. They launched it in 2019 but the current impact factor is already 23.8 and it is rising. I feel it has the potential to beat the Nature-Nature.
The interaction between dynein light chain Tctex-1 and osteoclast bone resorption regulator Rab3D plays a key role in modulating the bone-resorbing activities of osteoclasts.
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